IFNG and neoplasm: An alternative approach to increase the M1-to-M2 macrophage and the Th1-to-Th2 helper cell ratios is to inject anti-tumor cytokines, such as IL-12 and IFN-γ, to reinforce the anti-tumor positive feedback loops that polarize macrophages and naïve helper T cells into the M1 and Th1 phenotypes, respectively.