MMP9 and colorectal carcinoma: Moreover, the docking energy of apigenin with PTGS2 (−6.31 kJ/mol) was the lowest, followed by naringenin with PTGS2 (−6.20 kJ/mol), naringenin with MMP9 (−5.81 kJ/mol), and apigenin with MMP9 (−5.20 kJ/mol) (Figure 5), indicating that apigenin and naringenin in D. officinale were the most important active components, and PTGS2 and MMP9 were the most important targets that play the role of against CRC.