It has already been shown in a mouse model that a lack of AQP5 in the lacrimal gland and salivary gland seem to influence the aqueous component of the tear film and contribute to the autoimmune form of DED Sjögren's syndrome (48) and immunohistochemical examination of the human lacrimal gland in severe forms of dry eye due to Stevens-Johnson syndrome have demonstrated loss of AQP5 (51). The gene discussed is AQP5; the disease is Sjogren syndrome.