Among multilineage SM patients, the presence of the KIT D816V mutation is typically detected in genomic DNA (gDNA) of CD34+ hematopoietic stem and precursor cells, eosinophils, monocytes, and maturing neutrophils, and, to a less extent, also in T lymphocytes, in addition to bone marrow mast cells [5]. Here, KIT is linked to systemic mastocytosis.