ASXL1 and myelodysplastic syndrome: HIV portends a poor prognosis in MDS and patients have an increased prevalence of complex karyotypes characterized by monosomy 7 or deletion 7q at cytogenetic level, whereas at the molecular level, the most frequent alterations are somatic mutations in the ASXL1 exons11‐ 12, P53, and DNMT3A [3, 4, 5, 6].