In conclusion, our study shows that TARC is a valuable diagnostic biomarker for children with cHL, with a sensitivity of 97.9% and specificity of 100% for plasma (cutoff level of 942 pg/mL) and 100% sensitivity and 100% specificity for serum (cutoff level of 2257 pg/mL). Here, CCL17 is linked to classic Hodgkin lymphoma.