Similarly, after the use of the NLRP3 inflammasome inhibitor MCC950, the clearance of Aβ in APP/PS1 transgenic mice was significantly increased, and the tau pathology was significantly reduced, indicating again that the NLRP3 inflammasome plays an important role in AD (Swanson et al., 2019). Here, NLRP3 is linked to Alzheimer disease.