In addition, Aβ triggers inflammasome-related signaling in microglia, activates IL-1β and IL-18 via NLR family pyrin domain containing 3 (NLRP3)/apoptosis-associated speck-like protein containing a CARD (ASC)/Caspase1, thereby promoting AD progression through deleterious inflammatory responses (Yang et al., 2019; Zhao et al., 2020). This evidence concerns the gene NLRP3 and Alzheimer disease.