MAPT and Alzheimer disease: Thus tau post-translational modifications (PTMs) such as phosphorylations, acetylation, ubiquitination, glycation, glycosylation, SUMOylation, methylation, oxidation, and nitration, have a significant role in AD development, playing a critical role in tau localization, protein-protein interactions, maintenance of its levels, and modifying its aggregate structure (Alquezar et al., 2020).