Dysregulation of either process CMA, have been observed in fibroblasts from AD patients at the level of macroautophagy (Cuervo and Wong, 2014), and could explain the overexpression of CMA-associated chaperones such as HSP70 reported here (Figure 9) and the high expression of the lysosomal membrane receptor LAMP2 (Figure 2), given the association of these proteins (Wu et al., 2015). This evidence concerns the gene LAMP2 and Alzheimer disease.