Based on the gene expression data reported by Antonell et al. (2013) for 14 brain samples (from the posterior cingulate cortex, at the level of the thalamus) from 7 control individuals and 7 AD patients (M139T, V89L or E120G mutations in PSEN1), we detected significant differential gene expression (upregulation or downregulation) between FAD and control individuals in 3,400 genes (Supplementary Table 1). This evidence concerns the gene PSEN1 and Alzheimer disease.