Notwithstanding, it has to be taken into account that autophagy impairment in skin samples could not be an specific biomarker for AD, since autophagy is also impaired in skin diseases and other pathological conditions (Klapan et al., 2022); hence it has to be combined with other diagnostic criteria such as the detection of tau hyperphosphorylations and the clinical data. This evidence concerns the gene MAPT and Alzheimer disease.