Molecular, metabolic, and biochemical alterations have been identified in skin fibroblasts from AD patients (Sims et al., 1985, 1987; Peterson and Goldman, 1986; Sorbi et al., 1995; Lee et al., 2010; Pérez et al., 2017), and AβPP processing and Aβ deposition occur in non-neural tissues, supporting that AD is not limited to the brain and thus these facts strengthens the use of peripheral non-neuronal cells for AD research (Puig and Combs, 2013). This evidence concerns the gene APP and Alzheimer disease.