Furthermore, the lysosomal pathway is also critical for the metabolism of the Aβ peptide by eliminating autophagosomes containing the peptide, and increased LAMP2 and CatD levels have been observed in the latter process of AD pathology (Hoffman et al., 1998; Saido and Leissring, 2012; Sollvander et al., 2016; Whyte et al., 2017). This evidence concerns the gene LAMP2 and Alzheimer disease.