These effects on neural inflammation may be why IFNγ is inversely correlated with cognitive ability (Monteiro et al., 2016) and grey matter volume in the dorsal hippocampus (Monteiro et al., 2016), and may therefore contribute to grey matter loss and mild cognitive impairment (MCI) in patients with SA (Torelli et al., 2011). The gene discussed is IFNG; the disease is Cognitive impairment.