EZR and retinal degeneration: Importantly, we demonstrated that pharmacological activation of lysosomal biogenesis and function, through NSC668394-mediated inhibition of Ezrin, rescued both lipofuscin accumulation and PRs degeneration in miR-211−/− mice, pointing to a new lysosomal-based therapeutic intervention to treat retinal degeneration (Naso et al., 2020).