LRRK2 and Parkinson disease: The lysosomal autophagy system mainly degrades long-lived macromolecular proteins and affects the occurrence and development of PD by regulating the genes encoding the proteins leucine-rich repeat kinase 2 (LRRK2), β-glucocerebrosidase (GBA), vacuolar protein sorting-associated protein 35 (VPS35), and DNAJC13 (Maraganore et al., 2004).