SNCA and Parkinson disease: The main pathological features of PD have been replicated in an α-synuclein mouse model (Hasegawa et al., 2017), and oxidation, nitration, the ubiquitin-proteasome system, and the lysosomal autophagy system were all found to be closely related to the degradation of α-synuclein (Wong and Krainc, 2017).