HMOX1 and hepatocellular carcinoma: Knockdown of P62 expression resulted in upregulation of Keap1 expression, which enhanced the degradation of NRF2 and decreased the entry of NRF2 into the nucleus; the antioxidant proteins such as HO1, FTH1, and NQO1 were decreased and thus enhance the sensitivity of drug-induced ferroptosis in hepatoma cells [23].