GPX4 and intervertebral disk degenerative disorder: Injection of BMSC-derived EVs or EVs derived from circ_0050205-overexpressing BMSCs reduced total free iron in IDD mice, while injection of adenovirus containing sh-GPX4 negated the inhibitory effects of EVs derived from circ_0050205-overexpressing BMSCs on total free iron (Figure 7(f)).