Then, we investigated the subset of T cells exerting the main function of antitumor and found that the percentage of CD3+CD8+ cells in the irradiated primary tumor was increased to 1.5-fold and 2.7-fold of non-irradiated tumor in PD-L1 wt and PD-L1−/− mice, respectively (ures 2C–2E). The gene discussed is CD8A; the disease is neoplasm.