We also photographed and weighed the spleens of PD-L1 wt and PD-L1−/− mice after primary tumor IR and found that tumor-caused splenomegaly was significantly relieved by IR and HCQ treatment, but this retardation was partly reversed by administration of anti-IFNAR1 (Figures S3A and S3B). Here, IFNAR1 is linked to neoplasm.