Moreover, the lifespan of tumor-bearing mice of PD-L1−/− group was longer than that of PD-L1 wt mice, and RT on primary tumor prolonged the lifespan of both PD-L1 wt and PD-L1−/− mice and even extended the lifespan of PD-L1−/− mice to 30 days after tumor cells inoculation (Figure 1C). Here, CD274 is linked to neoplasm.