A sample dendrogram and a trait heatmap were constructed based on the sample distribution and the corresponding clinical data (age at initial pathological diagnosis, weight, gender, neoplasm histologic grade, pathological metastasis, pathological node metastasis, pathological tumor size, pathological stage, Pugh-Child score, cancer status, adjacent hepatic tissue, albumin levels, platelet count, prothrombin time result, relative family cancer history, fetoprotein value, Ishak fibrosis stage, and vascular infiltration) of HBV-related HCC patients (Figure 1(b)). This evidence concerns the gene F2 and hepatocellular carcinoma.