Monogenic epilepsies may be autosomal recessive (e.g., EPM2A/B or SLC13A5), autosomal dominant (e.g., CHRNA4), autosomal haploinsufficiency (e.g., SLC6A1), or X-linked (e.g., ARHGEF9) (5–10). This evidence concerns the gene SLC6A1 and epilepsy.