In our following study, we verified that the total expression of Bip, IRE1a, ATF-6, CHOP, BAX, caspase 12, cleaved caspase3/9, and cytosolic Ca2+ concentration within host cells were elevated after WT and ΔespF/pespF infection but not after ΔespF infection. The gene discussed is HSPA5; the disease is infection.