However, it is speculated that it is a small number of cells with lytic infection of EBV that promote NPC carcinogenesis and progression, because antibodies against lytic infection, such as EA-IgA and VCA-IgA, were found to be elevated several years before clinical onset of NPC, whereas levels of these antibodies were correlated with disease progression (Chien et al., 2001; Cao et al., 2011). The gene discussed is CD79A; the disease is nasopharyngeal carcinoma.