Carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1c (SREBP1c) are the key transcription factors of genes involved in hepatic DNL, which are closely implicated in the development of fructose-induced hepatic steatosis (Ter Horst and Serlie, 2017). Here, SREBF1 is linked to Hepatic steatosis.