Carbohydrate response element-binding protein (ChREBP) and sterol regulatory element-binding protein 1c (SREBP1c) are the key transcription factors of genes involved in hepatic DNL, which are closely implicated in the development of fructose-induced hepatic steatosis (Ter Horst and Serlie, 2017). The gene discussed is MLXIPL; the disease is Hepatic steatosis.