Additional studies showed that UUO-induced loss of Klotho in murine fibrotic kidneys and expression of renal fibrosis–associated proteins were attenuated by genistein administration via a mechanism associated with inhibiting histone 3 deacetylation of the Klotho promoter, suggesting that Klotho restoration can occur via epigenetic histone acetylation. Here, KL is linked to renal fibrosis.