It has also been found that ZNRF3 hinders the growth of cancer cells and promotes cell apoptosis by regulating the Wnt/β-Catenin/TCF signaling pathway (Zhou et al., 2013) for the reason that Wnt-1 inhibits apoptosis by blocking mitochondrial cytochrome C release, thereby inhibiting the activity of caspase-9 (Li et al., 2006; Brocardo and Henderson, 2008). Here, HNF4A is linked to cancer.