Numerous literature has investigated how ZNRF3 regulates the Wnt/β-Catenin signal, which is correlated with cancer (Clevers and Nusse, 2012) because Wnt helps the stabilization and nuclear localization of β-Catenin, which contributes to the formation of TCF/β-Catenin complex and recreation of other co-activators to promote gene activation like c-MYC and cyclin D1 (Ma et al., 2012). This evidence concerns the gene ZNRF3 and cancer.