GLP1R and type 2 diabetes mellitus: Recently, studies on GLP-1 RAs, DPP-4i, and SGLT-2i in fracture risk of type 2 diabetes patients showed that gender differences may not be enough to play a decisive role in the increase of fracture risk in T2DM (Driessen et al., 2015b; Hou et al., 2018; Rådholm et al., 2020; Davie et al., 2021).