In xenograft models of athymic nude mice subcutaneously injected with shNT-GPX4-iKO cells and shNF2-GPX4-iKO cells, knockdown of NF2 upregulates TFRC, ACSL4 and nuclear YAP, and doxycycline-induced GPX4 knockdown is able to eliminate cancer lesions. Here, ACSL4 is linked to cancer.