Previous studies have mainly focused on relevant genes, enzymes and signaling pathways associated with ferroptosis, including p53, GPX4, ACSL 4, SCL7A11, NFS1, etc. Recent studies have shown that some noncoding RNAs (e.g., miR-9 and miR-137) are also involved in the regulation of ferroptosis in cancer cells (Liu Y. et al., 2021), serving as oncogenes or tumor suppressor genes by indirectly mediating signaling pathways in the tumor micro-environment (Zhang et al., 2019). This evidence concerns the gene GPX4 and cancer.