Furthermore, many studies reported the anti-angiogenic effect of Cur and TQ against the A549 and HepG2 mouse xenograft model leading to reductions in tumor growth and vascularization targeting VEGF (Yoysungnoen et al., 2006, 2008; ElKhoely et al., 2015; Wang et al., 2015; Jiao et al., 2016; Li et al., 2018; Tian et al., 2021). Here, VEGFA is linked to neoplasm.