PIK3CA and cancer: Furthermore, because Cur, TQ, and DIM have different and common targets, we suggest treating different cancer cells with these drugs with time intervals even for 1 h in between and determine the most effective combination for each cancer types, especially mitogen-activated protein kinase (MAPK), matrix metalloproteinases (MMPs), and AKT/PI3K/mTOR pathways, as stated in Table 3.