As noted earlier, as NEU1 is one of the crucial factors in activating the TLR, it is conceivable that NEU1 deficiency may lead to impaired TLR activation (Karmakar et al., 2019), which in turn contributes to AD pathology (Schmidt et al., 1997; Arroyo et al., 2011; Song et al., 2011). Here, NEU1 is linked to Alzheimer disease.