Members of the Apocynaceae contain alkaloid ibogaine, which is used as a psychedelic drug for the treatment of substance addiction (Koenig and Hilber, 2015; Dey et al., 2017), ajmalicine, an alkaloid used as an antihypertensive drug used to treat high blood pressure (Wink and Roberts, 1998), and alstonine, an antipsychotic picralima alkaloid which prevents hyperlocomotion, memory deficit and social interaction deficit through antipsychosis mediated by 5-HT2A/C receptors (Dey et al., 2017). The gene discussed is HTR2A; the disease is hypertensive disorder.