TP53 and colorectal cancer: G0/G1 phase arrest, down-regulation of cell cycle progression Down-regulate expression of hexokinase II Induced dissociation of hexokinase II from the mitochondria led to mitochondrial-mediated apoptosis Upregulate EMT-suppressive miRNAs in 5-FU resistant cells Down-regulate BMI1, SUZ12, and EZH2 transcripts Upregulating p53 molecule expression Multiple signalling pathways such as AKT, Erk, and STAT3 inhibit colony formation in murine colorectal cancer cells