Caspase activation Inactivation of NF-κB Delayed cell cycle progression by downregulating cyclin B1 and cdk1 expression via inactivation of NF-κB Prevent tumour formation by inhibiting angiogenesis through the suppression of endothelial cell motility, proliferation, and tube formation Increase cellular adhesion to collagen and fibronectin, and inhibit angiogenesis in the colorectal cancer cell. Here, CDK1 is linked to colorectal cancer.