G0/G1 phase arrest, down-regulation of cell cycle progression Down-regulate expression of hexokinase II Induced dissociation of hexokinase II from the mitochondria led to mitochondrial-mediated apoptosis Upregulate EMT-suppressive miRNAs in 5-FU resistant cells Down-regulate BMI1, SUZ12, and EZH2 transcripts Upregulating p53 molecule expression Multiple signalling pathways such as AKT, Erk, and STAT3 inhibit colony formation in murine colorectal cancer cells. Here, EZH2 is linked to colorectal cancer.