APP and Alzheimer disease: After 4 days of learning and training, the time in the target quadrant and the number of crossing platform of APP/PS1 mice, Alu-Gal AD mice, and Alu AD mice were significantly lower than those of their control mice groups on the 5th day (Figure 2 and Figure 3), indicating that the spatial learning and memory abilities of the three kinds of AD model mice were significantly decreased.