Dauricine can significantly improve cognitive impairments in 3xTg-AD mice by decreasing Aβ plaques and hyperphosphorylated Tau and increasing the hippocampal ATP level by modulating the tricarboxylic acid cycle, synaptic vesicle cycle, glycolysis, and gluconeogenesis in 3xTg-AD mice (Chen Y. et al, 2021). The gene discussed is MAPT; the disease is Cognitive impairment.