For the purpose of studying the neuroprotective effects of BBMH on AD, three kinds of AD model mice including double transgenic APP/PS1 AD mice, Gal-Alu AD mice induced by the intraperitoneal injection of d-galactose combined with the intragastric administration of aluminum trichloride, and Alu AD mice induced by stereotactic brain injection of aluminum trichloride were prepared first. Here, GAL is linked to Alzheimer disease.