However, the escape latency of the BBMH-treated Alu-Gal mice group (Figure 1B) and Alu mice group (Figure 1C) was gradually shortened and approached to the control mice group (and/or sham operation group) on the 4th day, indicating that the learning and memory abilities of BBMH-treated Alu-Gal AD mice and Alu AD mice were greatly improved after BBMH administration. The gene discussed is GAL; the disease is Alzheimer disease.