After 4 days of learning and training, the time in the target quadrant and the number of crossing platform of APP/PS1 mice, Alu-Gal AD mice, and Alu AD mice were significantly lower than those of their control mice groups on the 5th day (Figure 2 and Figure 3), indicating that the spatial learning and memory abilities of the three kinds of AD model mice were significantly decreased. This evidence concerns the gene GAL and Alzheimer disease.