As mentioned previously, elevated Usp21 levels in HCC CL38 cells and the NDEA-induced HCC model decreased the level of H2Aub, which accounted for the increase in the mitotic marker H3S10p and the expression of lipocalin 2 with an oncogenic effect (Bhattacharya et al., 2016). Here, LCN2 is linked to hepatocellular carcinoma.