A series of published studies have demonstrated the significant protective role of ursolic acid against liver fibrosis and mechanical insights ranging from the inhibition of hepatic stellate cell (HSC) activation (Wang et al., 2011; Yu et al., 2017), hepatic circadian rhythm regulation (Kwon et al., 2018), and gut dysbiosis improvement (Wan et al., 2019; Wan et al., 2020) to NADPH oxidase 4 (NOX4)/NOD-like receptor protein 3 (NLRP3) inflammasome pathway suppression (Nie et al., 2021) and oxidative stress repression through LKB1-AMPK signaling activation (Yang et al., 2015). This evidence concerns the gene NOX4 and Hepatic fibrosis.