AKT1 and systemic lupus erythematosus: KEGG pathway indicated that the DAPs were mainly involved in immune-related pathways, including systemic lupus erythematosus, antigen processing and presentation, phagosome, the PPAR signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, and complement and coagulation cascades (Fig. 4).