Although our study found that the RALA c.G482A variant activated the mTOR pathway and caused cortical neuronal migration disorders, considering that children carrying this variant have epilepsy, further studies are required to better correlate genotype with phenotype as to how RALA c.G482A causes FCD and subsequently affects the electrophysiological properties of neurons, ultimately leading to epilepsy. Here, RALA is linked to fleck corneal dystrophy.