Owing to the multiple roles of SYK in the cell, the dysfunction of SYK signaling has been reported in various diseases and disorders such as allergic rhinitis, asthma, autoimmune disease rheumatoid arthritis, psoriasis, systematic lupus erythematosus, leukemia, and lymphomas (Kaur et al., 2013). This evidence concerns the gene SYK and rheumatoid arthritis.