Expression of LMP1 in NPC cells recruits T regulatory cells (Tregs) through NF-κB signaling activation, which distributes around the tumor and contributes to inhibit the activation of innate cytotoxic T-cell responses; the Tregs enhances the secretion of the chemokine CCL20 and IL-10 and increases the migration of itself toward the tumor (Marshall et al., 2003; Baumforth et al., 2008), subsequently contributing to play the immune suppressive functions. The gene discussed is IL10; the disease is neoplasm.