Similarly, targeting the AMPK signaling by metformin and AICAR (Lo et al., 2013; Lu et al., 2016) and modulating the activity of NF-κB signaling by NBD (Zhu et al., 2016b; Zhang et al., 2017) in EBV-associated epithelial cells have attenuated the EBV and its oncoproteins-droved cell growth and malignant transformation, suggesting that disrupting the above mentioned pathways by related inhibitors may provide an additional benefit to antiglycolytic therapies for EBV-infected NPC. Here, NFKB1 is linked to nasopharyngeal carcinoma.