LMP1 expression that accelerated the aerobic glycolysis also causes the NPC cells to be insensitive to radiotherapy; Xiao and colleagues reported the exposure of the LMP1-expressed NPC cells into irradiation: the apoptotic level was high if the glycolytic enzyme HK2 knocks down further (Xiao et al., 2014). The gene discussed is HK2; the disease is nasopharyngeal carcinoma.