Consistently, EBV infection was showed to downregulate the expression levels of CYLD in NPC cells (Li et al., 2021), and CYLD deficiency could increase the transcriptional activity of PFKFB3, which is a key regulator of glycolysis, to enhance glycolysis (Wang et al., 2022). The gene discussed is CYLD; the disease is Epstein-Barr virus infection.