Cecal infection by S. Enteritidis induced the activation of the NOD-like receptor (NLR) signaling pathway within 4-hours post-infection probably via the prototypic NOD-1 pathway which sense the cytosolic presence of bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of both the NF-κB and MAPK signaling pathways. The gene discussed is NFKB1; the disease is infection.