To date, the majority of the studies in the chicken-Salmonella interaction has been microbe-centric, concentrating on the pathogen’s infection of the bird intestine by using the Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) that encode a specialized type III secretion system (T3SS) to secrete multiple protein effectors into the intestinal epithelium which manipulate the host cell biology to aid in bacteria invasion, intracellular survival, and to modulate host immune responses (Barrow et al., 2012; Figueira and Holden, 2012; Wigley, 2014; Eng et al., 2015). The gene discussed is SPI1; the disease is infection.