INS and Hypoinsulinemia: The success of inducing diabetes mellitus (DM) was also evident by the insulin profile of the rats (Table 4, diabetic group), which did not exhibit hypoinsulinemia, which usually occurs from a single STZ administration, but showed a significantly different form of hyperinsulinemia (3.79 ± 0.49 μU/mL) compared with the normal group (2.55 ± 0.55 μU/mL; P < 0.001).