In addition, the study verified the reversal of chondrocyte apoptosis by decreasing m6A levels of AC008 after FTO overexpression in chondrocytes, and finally concluded that FTO-dependent m6A demethylation-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p-AQP1/ANKH axis (Yang et al., 2021). This evidence concerns the gene ANKH and osteoarthritis.