In addition to this, found that the level of m6A in bone marrow mesenchymal stem cells (BMSCs) was decreased in paraffin sections of femurs from mice knocked out of Mettl3, and found that the trabeculae of the distal femoral epiphysis of mice exhibited a pathological phenotype similar to that of osteoporosis by μCT. Here, METTL3 is linked to osteoporosis.