LMNA and Arrhythmia: Notably, almost half of the LMNA cardiomyopathy patients succumb to sudden cardiac death as a result of a fatal arrhythmia, and conduction defects associated with LMNA mutations can substantially precede the onset of structural heart modification, meaning that subtle but fatal arrhythmias may occur before any noticeable change in the function (Hasselberg et al., 2018).