An increasing pool of data suggests that microbiota or its components and metabolites can modulate NF-κB signaling leading to CRC development (Kostic et al., 2013; Pallett et al., 2014; Tsoi et al., 2017; Yang et al., 2017; Chung et al., 2018; Long et al., 2019; Chen et al., 2020). This evidence concerns the gene NFKB1 and colorectal carcinoma.