Recently, growing studies have revealed aberrant HO-1 accumulation in the nucleus of tumor cells, and antitumor therapy could further upregulates nuclear HO-1 expression (Sacca et al., 2007; Li et al., 2008; Degese et al., 2012; Gandini et al., 2012; Tibullo et al., 2013; Dennery 2014). Here, HMOX1 is linked to neoplasm.