HMOX1 and Familial prostate cancer: The upregulation of nuclear HO-1 has shown in several types of cancer, including HNSCC (Gandini et al., 2012), chronic myeloid leukemia (Tibullo et al., 2013), cervical cancer cell (Hsu et al., 2015), lung cancer (Hsu et al., 2015), colorectal cancer (Yin et al., 2014), and prostate cancer (Maines and Abrahamsson 1996; Sacca et al., 2007), and are frequently correlates with cancer progression.