Increases in YAP-1 activity are associated with cell proliferation and cancers (Halder and Johnson, 2011), whereas phosphorylation of YAP-1 via MST1/2-LATS1/2 results in its cytoplasmic retention, and subsequent degradation, leading to loss of transcriptional activity and induction of apoptosis (Halder and Johnson, 2011). The gene discussed is LATS1; the disease is cancer.