Variants in factors that modulate cell apoptosis, such as FAS receptor and its ligand (FASL) (Zhu et al., 2011), Caspase-9 (Sun et al., 2011; Mu et al., 2013), tumor necrosis factor related apoptosis-inducing ligand (TRAIL) (Du et al., 2015), and Death receptor 4 (DR4) (Tan et al., 2012) have been found to be associated with IDD. This evidence concerns the gene TNFRSF10A and intervertebral disk degenerative disorder.