In the IS1 mesothelioma patients, the expressions of EIF2AK2, MET, and TLR3 were notably increased in the TCGA cohort, whereas CLCX10, EIF2AK2, EIF2AK3, FPR1, IFNAR1, IFNAR2, LRP1, MET, P2RX7, TLR3, and TLR4 were significantly overexpressed in the GEO cohort. Here, EIF2AK2 is linked to mesothelioma.