In the IS1 mesothelioma patients, the expressions of EIF2AK2, MET, and TLR3 were notably increased in the TCGA cohort, whereas CLCX10, EIF2AK2, EIF2AK3, FPR1, IFNAR1, IFNAR2, LRP1, MET, P2RX7, TLR3, and TLR4 were significantly overexpressed in the GEO cohort. The gene discussed is P2RX7; the disease is mesothelioma.