Based on our results, we hypothesize that hypoxia produced during tumor growth further contributes to increased angiogenesis in the tumor microenvironment of NSCLC, resulting in robust expression of integrin αVβ3 and high RGD SUVs, and it downregulates the tumoral PD-L1 expression through the HIF-EMT axis simultaneously. The gene discussed is CD274; the disease is neoplasm.