Researches in rodents have provided evidence of sex differences in the role of adipocyte-derived factors in aldosterone secretion, in obese female rats, leptin may contribute to increased blood pressure by stimulating secretion of aldosterone, but the importance of leptin-induced increases in aldosterone secretion in the setting of obesity in male rodents was not observed (40). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.