NF-κB in the kidney tissue of the DM and DKD groups was upregulated; NF-κB expression in the DKD group was higher than that in the DM group, and the difference was statistically significant (all P< 0.05) (see Figure 5A).In the DM group, a small amount of glomerular stroma and mild connective tissue hyperplasia can be seen in the interstitium, and blood vessels and capillaries are congested. Here, NFKB1 is linked to diabetic kidney disease.