Specifically, lower LEPR protein expression was associated with ER- status, triple-negative (TN) subtype (40), while lower gene expression of ADIPOQ, ADIPOR2, LEP, and LEPR were associated with more aggressive breast tumor features, including higher tumor grade, larger tumor size, ER- status, and human epidermal growth factor receptor 2 (HER2)-enriched and TN subtypes (41). This evidence concerns the gene ESR1 and neoplasm.