Nonetheless, our findings suggest that distribution of adiposity and adiposity-related expression profiles of the adipokines and adipokine receptors, especially LEP and LEPR, in the local organ might have differential impacts on breast cancer based on tumor subtype, and the crosstalk between ER and adipokine biomarkers and other inflammatory biomarkers might play a role (59). The gene discussed is LEPR; the disease is breast carcinoma.