The findings revealed that age, duration, LDL-C, UA, and the presence of DR were still independently associated with the risk of DPN, while TC, Cr, BUN, eGFR, CRP, SBP, and the presence of DN were no longer related (Table 8, **p < 0.01, *p < 0.05, p>0.05). This evidence concerns the gene CRP and liver dysplastic nodule.