Currently, the pathophysiology of OHSS is not clear enough, possible casual factors include estradiol, luteinizing hormone, human chorionic gonadotropin (hCG), inflammatory mediators, the renin-angiotensin system, vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-β) (8, 10). This evidence concerns the gene VEGFA and ovarian hyperstimulation syndrome.