Genomic analysis of single-cardiomyocyte RNA-seq data from human heart biopsies of pre- and post-implanted patients with left ventricular assist device revealed that implantation normalized this Ackr3 upregulation in both ischemic and non-ischemic cardiomyopathies (97) indicating a crucial role of ACKR3 in human cardiomyocytes. This evidence concerns the gene ACKR3 and ischemic cardiomyopathy.