Furthermore, treatment of these mice with ACKR3 agonist TC14012 attenuated these defects and restored cardiac function with a marked activation of pERK signalling, suggesting that activation of pERK signalling pathways induced by the binding of TC14012 to ACKR3 prevented the progression of cardiac hypertrophy (67) (Figure 1). Here, EIF2AK3 is linked to cardiac hypertrophy.