ACKR3 and Ventriculomegaly: Interestingly, conditional specific deletion of Ackr3 in cardiomyocytes (αMHC-Cre+/− CXCR7flox/flox model) in mice leads to excessive left ventricular dilatation and major systolic dysfunction after MI demonstrating that cardiomyocyte ACKR3 protects the heart after ischemia (68).