In human, expression levels of both CXCL12 and ACKR3, but not that of CXCR4, are increased in the peri-infarction area of ischemic cerebral cortex, suggesting that CXCL12 modulates the repair of the brain after a stroke through ACKR3 activation (89). The gene discussed is CXCL12; the disease is stroke disorder.