Interestingly, conditional specific deletion of Ackr3 in cardiomyocytes (αMHC-Cre+/− CXCR7flox/flox model) in mice leads to excessive left ventricular dilatation and major systolic dysfunction after MI demonstrating that cardiomyocyte ACKR3 protects the heart after ischemia (68). Here, ACKR3 is linked to ischemia.